Young Investor Award past winners

2016

Dr Elizabeth Curtis Fracture Incidence and secular trends in the United Kingdom 1988-2012: Variation by age, sex, geographic location, ethnicity and socioeconomic status
Dr Jelena Blagojevic The scleroderma fibrotic score: A useful serum test in the diagnosis of early scleroderma
 2015
Dr Sam Norton Impact of conventional disease modifying therapy on mortality risk in two UK rheumatoid arthritis cohorts
Dr Maria Di Cicco Synovial Pathotype predicts response to TNFalpha inhibitors in patients with rheumatoid arthritis
 2014
Dr Matthew Webber Cardiac MRI abnormalities are associated with arrhythmogenic events in systemic sclerosis: Evidence for the use of the implantable cardiac defibrillator as primary prevention of sudden cardiac death
Dr Clare Thornton Methotrexate: A novel mechanism for vasculoprotection in chronic system inflammation
Ms Joanna Nikitorowicz-Buniak Abnormal differentiating keratinocytes in epidermis of systemic sclerosis patients show enhanced secretion of CCN2 and S100A9
Dr Sabrina R Kapoor Metabolic profiles of synovial fibroblasts: Implications for disease processes in inflammatory arthritis
Dr Audrey Low Incidence and severity of myocardial infarction in subjects receiving anti tumour necrosis factor drugs for rheumatoid arthritis: Results from linking the British Scoiety for Rheumatology Biologics register for rheumatoid arthritis and myocardial ischaemia national audit project
 2013
Mr Jonathan Baker The role of protein kinase D signalling in the induction of matrix metalloproteinases in human articular chondrocytes 
Dr Elena Lugli Widespread citrullination in healthy and inflamed lung tissue as a priming site for autoimmunity in RA
Mr Martin Fitzpatrick Macrophage metabotypes in the hypoxic inflamatory environment assessed using metabolomic profiling
 2012  
Miss Youridies Vattakuzhi
Dual specificity phosphatase 1 is a crucial negative regulator of inflammatory osteolysis and a mediator of therapeutic effects of dexamethasone in collagen-induced arthritis

Dr Jennifer Humphreys

Incidence of rheumatoid arthritis in the UK using the 2010 ACR/EULAR classification criteria; and comparison with estimates using the 1987 ACR criteria

Dr Joanna Cobb

Analysis of the immunochip in a large cohort of oligo- and polyarthritis juvenile idiopathic arthritis cases confirms previous and identifies novel associations

Dr Amy Naylor

The mesenchymal stromal cell marker cd248 regulates inflammatory arthritis and bone formation

Dr Clare Warrell

Is there an association between warfarin and survival in ssc-pah patients treated with first line bosentan monotherapy?

2011

Dr Andrew Kinloch  Immunisation with porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4IE transgenic mice
Mrs Elizabeth Camacho The association between helplessness, socioeconomic status, and disease outcome in patients with inflammatory polyarthritis
Ms Rebecca-Jane Law
Perceptions of issues relating to exercise and joint health in rheumatoid arthritis: a UK-based questionnaire study
Dr Louise Mercer Risk of cancer in patients receiving non-biologic disease modifying therapy for rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register (BSRBR)
Dr Benjamin Schreiber Diagnosis and prognosis of pulmonary arterial hypertension in SLE and SSC
2010
Dr James Galloway Risk of septic arthritis in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the BSR Biologics Register (BSRBR)
Dr Sarah Wythe Targeting the inflamed microvasculature in rheumatoid arthritis
Dr Laura Coates  Achieving minimal disease activity (MDA) criteria with anti-TNF therapy in psoriatic arthritis can prevent progressive joint damage
Dr Luke Gompels  Quantifying in vivo fluorescence imaging in murine arthritis by targeting E-selectin
Dr Michele Bombardieri  Rheumatoid synovial fibroblasts support aid expression and Ig class-switching in B cells via a BAFF-dependent TLR3-stimulated pathway
Dr Louise Mercer The risk of non-melanoma skin cancer in patients receiving anti-TNF therapies for rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register

2009

Dr I Atchia  Musculoskeletal ultrasound predicts response to corticosteroid injection in moderate-severe hip osteoarthritis
Dr M Bombardieri  Il-23 overexpression as immunological signature of subclinical intestinal inflammation in ankylosing spondylitis
Dr E Derrett-Smith  Vasculopathy in a TGF-β; dependent mouse model of systemic sclerosis
Dr S Haque  Impaired endothelial progenitor cell function and early atherosclerosis in systemic lupus erythematosus (SLE)
Dr E Vital  How to manage non-response to rituximab? Predictors and outcome of retreatment provide a treatment algorithm
Ms N Wegner  Endogenously citrullinated proteins from porphyromonas gingivalis as a candidate source of priming autoantigens in rheumatoid arthritis

2008

Dr S Wright A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus
Dr V Panoulas  Genetic regulation of hypertension in patients with rheumatoid arthritis
Dr A Bennett
Early inflammatory back pain and mri sacroiliitis: severity of osteitis at baseline and HLA-b27 predict ankylosing spondylitis at 8 years
Dr F Humby  Activation-induced cytidine deaminase supports self sustained autoantibody production within RA synovium
Dr K Nistala  Il-17-producing T cells are enriched in the joints of children with arthritis, and correlate with clinical phenotype
Dr C L Gorman Polymorphisms in the CD3Z gene influence TCR zeta expression in healthy controls and in SLE

2007

Dr S Hamdulay  Statins and rapamycin: therapeutic synergy in vascular cytoprotection
Dr S Carty  Combination therapy with etanercept and SGP130 for rheumatoid arthritis is more effective than monotherapy
Dr K Wartolowska
Clinical and experimental pain processing in rheumatoid arthritis patients treated with anti-TNF
Dr H Chinoy
The diagnostic utility of serology testing for predicting the risk of cancer-associated myositis
Dr F Barone
Aberrant expression of B cell survival factors in salivary gland’s malt lymphomas during sjögren’s syndrome
Dr Z Betteridge
Anti-sumo E1: a novel autoantibody in dermatomyositis directed against the small ubiquitin-like modifier activating enzyme

2006

Dr A El-Metwally
Risk factors for development of musculoskeletal pain in preadolescents: a prospective
Dr A Judge
The effects of surgical volumes and training centre status on outcomes following total joint replacement in England
Dr R Lamb
Monogenic syndromes reveal candidate loci of importance for JIA susceptibility
Dr K Lundberg
Reactivity of RA sera with citrullinated-alpha-enolase peptides: development of a new diagnostic elisa
Dr K E.S. Poole
A single dose of zoledronate prevents bone loss after acute stroke
Dr J Prior
Studies on the potential of clinical acoustic emissions as a new assessment tool for knee arthritis

2005

Dr E Clark
Bone mass in childhood is not related to measures of parental deprivation
Dr P Ho
Psoriatic arthritis is associated with a Crohn’s disease gene
Dr L Jarvis
CD8+ regulatory T cells in patients with ankylosing spondylitis (AS)
Dr E Pattison
Environmental risk factors for the development of psoriatic arthritis: a case control study
Dr E Smith
A novel multi-cellular model of leucocyte recruitment into the rheumatoid synovium reveals a critical role for interleukin-6
Dr G Treharne
Life satisfaction and depression across 1 year with rheumatoid arthritis: testing interactive effects of coping resources and perceived stress

2004

Dr K Atherton
Predicting persistence of neck pain following a motor vehicle accident: a prospective study of persons attending emergency department
Dr N Dalbeth
The angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis’
Dr A Kinderlerer
Upregulation of membrane-bound complement regulatory proteins by atorvastatin protects vascular endothelium against complement-mediated injury during hypoxia-reoxygenation
Dr P Philippidis The haemoglobin scavenger receptor CD163 mediates macrophage interleukin-10 and haem oxygenase-1 syntheseis: an inducible cytoprotective pathway against haemoglobin mediated oxidative vascular injury
Dr K Raza Very early rheumatoid arthritis is characterised by a unique and transient T cell and stromal cytokine profile
Dr A Timms The IL1 gene cluster is a major locus determining susceptibility to ankylosing spondylitis

2003

Dr F Barone CXCL13 and CCL21 play a key role in ectopic lymphogenesis in Sjögren’s Syndrome
Dr M K Javaid Umbilical vein calcium concentration and maternal height predict childhood bone mineral content at nine years
Dr G Jones Physical activity and adverse psychosocial behaviour predict the onset of widespread pain in children
Dr W Kafienah Inhibition of cartilage degradation: a combine gene therapy and tissue engineering approach
Dr D O'Gradaigh Cytokine-activated T-cells support osteoclastogenesis from peripheral blood mononuclear cell precursors
Dr A Lyn Tan The role of metacarpophalangeal joint anatomical factors on the distribution of synovitis and bone erosion in early rheumatoid arthritis

2002

Dr A Afuwape Adenoviral delivery of soluble VEGF receptor (sFLT-1) abrogates disease activity in murine collagen induced arthritis
Dr N Goodson Cardiovascular risk factors are not increased prior to the onset of inflammatory polyarthritis
Dr E Zeggini Development of tumour necrosis factor (TNF) polymorphism genotyping and association study with juvenile idiopathic arthritis (JIA)
Dr R Jeffery The -174 polymorphism of IL-6 alters transcription factor binding and forms functionally significant allelic associations in systemic arthritis
Dr J Newton LTA-TNF halpotype studies identify additional rheumatoid arthritis susceptibility regions in the MHC
Dr C McCarthy Knee classes are superior to home exercises in reducing pain and increasing function in patients with knee osteoarthritis: results from a randomised clinical trial

2001

Dr C Blades Development of a new model to investigate lymphocyte migration into human peripheral lymph nodes (HPLN) into transplanted SCID mice
Dr M Carulli Role of BCA-1 chemokine (CK) in the organization of follicle-like structures in Rheumatoid arthritis (RA)
Dr K Walker-Bone Brawn or brain? Mechanical and psychosocial risk factors for neck and upper limb musculoskeletal disorders
Dr S Lane Is farming a risk factor for primary systemic vasculitis (PSV)?
Dr A W Morgan Linkage disequilibrium at the FC gamma receptor locus and association of an FC gamma receptor haplocyte with rheumatoid arthritis (RA) in two distinct ethnic groups
Dr S Richards The Kings prescription fibromyalgia intervention trial (KeepFit)

2000

Dr M Ali Comparison between persistent and self-limiting synovitis by analysis of gene expression
Dr F Birrell Predicting the need for total hip replacement in patients newly presenting to primary care with hip pain; a prospective cohort study
Dr P R Colville-Nash Prostaglandin F2α produced by inducible cyclooxygenase may contribute to the resolution of inflammation
Dr L Harper Apoptosis and its importance in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis
Dr T Lawrence Inhibition of NF-B activity and MCP-1/JE release in vivo, through induction of the heat shock response
Dr M S Lillicrap The repertoire of human heat shock protein 60 responsive CD40+ T cell clones from a healthy individual contains more than one subset