11 August 2024


New resources to support more clinicians to recognise the rare and devastating condition HLH have been developed by the Getting It Right First Time (GIRFT) team, in association with BSR and patient support group Histio UK.

GIRFT led a collaborative, cross-specialty group of clinicians towards the first consensus pathway for the little-known haemophagocytic lymphohistiocytosis (HLH), to raise awareness among acute care providers so that HLH is considered more often as a diagnosis. If diagnosed, the pathway and its accompanying guidance can steer clinical teams through the patient’s treatment and onward support.

The resources showcase consensus recommendations for care across the patient pathway and best practice case studies from teams who have significantly reduced their mortality rates.

Read and download the pathway for HLH

Read and down the guidance for guidance for the diagnosis, treatment, management and governance for HLH

While GIRFT’s work has been led by rheumatologists, the pathway, guidance and webinar are equally relevant for colleagues in emergency medicine, haematology, general medicine, infectious diseases, critical care, paediatrics, immunology, rare diseases, obstetrics and pharmacy, as well as operational colleagues and commissioners.

Peter Lanyon, GIRFT’s joint clinical lead for rheumatology was among the lead authors of the pathway and guidance, along with Jessica Manson (consultant rheumatologist at University College London), Rachel Tattersall (adolescent and adult rheumatology consultant at Sheffield Teaching Hospitals and Sheffield Children’s) and Lesley Kay (GIRFT’s joint clinical lead and NHS England national clinical director for MSK).

Peter said: “Patients can present with HLH in any part of acute medicine, so increasing awareness across the system can mean earlier recognition and treatment and potentially more lives saved.

“We hope these resources will start a national clinical conversation about HLH among all providers of acute care, so that the syndrome is considered - and hopefully ruled out - as soon as possible.”

Join the webinar to coincide with Histiocytosis Awareness Month (September), GIRFT is holding a webinar to discuss and consider any questions on the guidance. 

Working together to improve care and outcomes for people with suspected haemophagocytic lymphohistiocytosis (HLH) takes place on Thursday 26th September from 12.30pm to 1.30pm. 

Register here